Folic acid and methotrexate for rheumatoid arthritis

The folic acid has been great on clearing up the bleeding mouth ulcers I had for years before diagnosis. I have since developed osteoporosis, probably as a side effect of the predisone and the methotrexate. Sherre, I have mixed connective tissue disease of RA and lupus, and was originally put on methotrexate, folic acid, predisone. Use a soft toothbrush and electric razor. Report any unusual bleeding to your doctor. Certain medicines will increase methotrexate side effects and may not be taken before, during, or shortly after receiving methotrexate.